| 张璐.ICP-OES法测定甘油磷酸钠注射液中的钠和磷的含量[J].中国药品标准,2023,24(2): |
| ICP-OES法测定甘油磷酸钠注射液中的钠和磷的含量 |
| The content of of sodium and Phosphorus in sodium glycerophosphate Injection was determined by ICP-OES |
| 投稿时间：2022-06-24 修订日期：2023-03-30 |
| DOI： |
| 中文关键词: 甘油磷酸钠注射液 钠 磷 含量测定 电感耦合等离子体原子发射光谱 |
| 英文关键词: sodium glycerophosphate injection sodium phosphorus content determination Inductively coupled plasma optic emission spectrometry |
| 基金项目:肠内外营养制剂检测研究与评价 |
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| 中文摘要: |
| 目的：采用电感耦合等离子体原子发射光谱（ICP-OES）法同时测定甘油磷酸钠注射液中钠和磷的含量。方法：等离子体气：12L·min-1；辅助气：0.3L·min-1；雾化气：0.6L·min-1；射频功率：1300W；泵流速：1.5mL·min-1；分析波长：钠为589.592nm，磷为213.617nm。结果：钠的线性范围为1～9μg·mL-1（r=0.9996），平均回收率为97.8%，磷的线性范围约为1～5μg·mL-1（r=0.9999），平均回收率为100.0%。2批样品测得的钠和磷含量结果与原标准方法基本一致。结论：建立的ICP-OES法同时测定甘油磷酸钠注射液中钠和磷的含量方法可用于快速大批量测定样品，为更合理地控制甘油磷酸钠注射液的质量提供参考。 |
| 英文摘要: |
| Objective：To establish a Inductively coupled plasma optic emission spectrometry (ICP-OES) method for the simultaneous determination of sodium and phosphorus in sodium glycerophosphate injection. Methods: Plasma gas:12L·min-1, auxiliary gas:0.3L·min-1, atomization gas: 0.6L·min-1, radio-frequency power: 1300W, pump flow rate: 1.5mL·min-1, analysis wavelength: sodium 589.592nm, phosphorus 213.617nm. Results: The liner range of sodium was 1-9μg·mL-1 (r=0.9996) , and the average recovery was 97.8%. The liner range of phosphorus was 1-5μg·mL-1 (r=0.9999) , and the average recovery was 100.0%. The results of sodium and phosphorus content in 2 batches of samples were basically consistent with the original standard method. Conclusion: The ICP-OES method for simultaneous determination of sodium and phosphorus in sodium glycerophosphate injection can be used for rapid determination of sodium glycerophosphate injection in large quantities. It provides reference for more reasonable control of the quality of sodium glycerophosphate injection. |
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