| 顾晓风,沈心,姚玲.复方薄荷脑软膏的质量标准研究[J].中国药品标准,2023,24(1): |
| 复方薄荷脑软膏的质量标准研究 |
| Study on the quality standard of compound menthol ointment |
| 投稿时间：2022-04-01 修订日期：2023-01-30 |
| DOI： |
| 中文关键词: 复方薄荷脑软膏 薄荷脑 樟脑 水杨酸甲酯 质量标准 |
| 英文关键词: Compound menthol ointment Menthol Camphor Methyl salicylate Quality standard |
| 基金项目: |
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| 摘要点击次数: 135 |
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| 中文摘要: |
| 目的：提高复方薄荷脑软膏的质量标准。方法：以HP-INNOWAX石英毛细管柱为色谱柱,程序升温,进样口温度200 ℃,检测器(FID)温度250 ℃。结果：样品在薄荷脑、樟脑、水杨酸甲酯、桉油精和α-蒎烯对照品相同保留时间处出现色谱峰；薄荷脑、樟脑和水杨酸甲酯的标准曲线呈良好的线性关系(r ≥ 0.9990),平均回收率分别为98.56%、99.27%、98.47%,RSD为1.64%、1.77%、2.34%(n = 9)。结论：该方法准确可靠,可行性强,能有效控制该制剂的质量。 |
| 英文摘要: |
| Objective: To modify and improve the quality standard of compound menthol ointment. Methods: The capillary column was Agilent HP-INNOWAX, with temperature programmed. The inlet temperature was 200 ℃ and FID detector temperature was 250 ℃. Results: The test solution had peaks at the same retention time with menthol, camphor, methyl salicylate, eucalyptol and α-pinene. Menthol, camphor and methyl salicylate had good linear ranges (r ≥ 0.9990). The average recoveries were 98.56%, 99.27%, 98.47% and RSDs were 1.64%, 1.77%, 2.34% (n = 9) respectively. Conclusion: The method developed is accurate and reliable, which can be more effectively used in the quality control of compound menthol ointment. |
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