文章摘要
姚永青,刘英.对《中国药典》双氯芬酸钠重金属检查的商榷[J].中国药品标准,2019,20(1):5-8
对《中国药典》双氯芬酸钠重金属检查的商榷
Discussion on the heavy metal examination of Diclofenac Sodium in Chp2015Yao Yongqing,Liu Ying*(Henan Institute for Food and Drug Control,Zhengzhou 450003)
投稿时间:2018-05-22  修订日期:2019-01-14
DOI:
中文关键词: 重金属  双氯芬酸钠
英文关键词: heavy metal  Diclofenac Sodium
基金项目:
作者单位E-mail
姚永青* 河南省食品药品检验所 yaoyongqing.1984@163.com 
刘英 河南省食品药品检验所 yaoyongqing.1984@163.com 
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中文摘要:
      目的:对《中国药典》双氯芬酸钠重金属检查方法进行完善。方法:分别采用现行标准和优化方法检查双氯芬酸钠中的重金属并对结果进行分析。结果:依据现行标准检测,结果丙管颜色不浅于甲管,甲管和乙管颜色相近;对现行标准进行优化,分别在三管中加氨水使溶液对酚酞指示液显中性,再分别加醋酸盐缓冲液和硫代乙酰胺试液,摇匀,放置,结果丙管颜色不浅于甲管,乙管颜色不深于甲管。结论:依据重金属检查的原理,优化方法更为严谨,更具可操作性,能更好的对样品中的重金属进行控制。
英文摘要:
      Objective: Improvement of the method of heavy metal examination of Diclofenac Sodium in Chinese Pharmacopoeia. Methods: The current standards and improved methods are used to examine the heavy metals in Diclofenac Sodium and and analyse the results. Results: Test by the current standards, the color of the C tube is not lighter than the A, the color of the A tube is close to the B. Improve the current standards, Add Ammonia to three tubes respectively to make sure the solution was neutral to Phenolphthalein indicator solution, then add Acetate buffer and Thioacetamide solution to the three tube respectively, shake well and place, the color of the C tube is not lighter than the A, the color of the B is not lighter than the A. Conclusion: According to the principle of Heavy metal inspection, the improved method is more rigorous, more maneuverable, and it can better control the Heavy metals in samples.
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