文章摘要
王秀芹,林彤,江英桥.地黄丸类中成药泽泻薄层鉴别方法研究*[J].中国药品标准,2018,19(2):146-150
地黄丸类中成药泽泻薄层鉴别方法研究*
Study on identification of Rhizoma Alismatis in Chinese patent medicines Dihuang Pills by TLC*
投稿时间:2018-01-22  修订日期:2018-04-08
DOI:
中文关键词: 六味地黄丸  地黄丸类  泽泻  薄层色谱鉴别
英文关键词: Scutellaria barbata granules  TLC  HPLC  fingerprint  scutellarin  apigenin
基金项目:广州市科技计划项目(合同编号201510010106);2015版《中国药典》专项课题研究“中国药典中成药薄层色谱彩色图集”(课题编号:440)
作者单位E-mail
王秀芹* 广州市药品检验所 401507797@qq.com 
林彤 广州市药品检验所  
江英桥 广州市药品检验所  
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中文摘要:
      目的 : 修订《中国药典》2015年版中六味地黄丸中泽泻的薄层鉴别方法,并建立地黄丸类中成药(杞菊地黄丸、知柏地黄丸、桂附地黄丸、明目地黄丸、麦味地黄丸和归芍地黄丸)中泽泻的薄层色谱鉴别方法。方法:以泽泻对照药材和23-乙酰泽泻醇B对照品为对照,采用硅胶G 薄层板,以环己烷-乙酸乙酯(1︰1)为展开剂,5%香草醛硫酸溶液显色,105℃加热至斑点清晰,可见光检视。结果: 新修订的泽泻药材薄层鉴别方法斑点显色清晰,分离度好,具有专属性。 结论: 新修订泽泻薄层鉴别方法,可用于《中国药典》六味地黄丸及其他地黄丸类中成药中泽泻的质量控制,达到同一药味在相关品种中的鉴别方法一致的目的。
英文摘要:
      Objective : Revise the TLC method of Rhizoma Alismatis in Liuwei Dihuang Pills of Chinese Pharmacopoeia 2015 edition and establish a TLC method to indentify Rhizoma Alismatis in Dihuang Pills Chinese patent medicines including Qiju Dihuang Pills,Zhibai Dihuang Pills,Guifu Dihuang Pills,Mingmu Dihuang Pills,Maiwei Dihuang Pills and Guishao Dihuang Pills. Methods: Rhizoma Alismatis reference drug and 23-acetate alisol B reference were used in the the revised method . The stationary phase was silica gel. The mobile phase was cyclohexane and ethyl acetate(1:1). Spray with a 5% solution of vanillin in sulfuric acid and heat at 105℃ until the colours of the zones become visible and examine in daylight. Results: The newly revised identification method of Rhizoma Alismatis has good specialization. The TLC spots were clear and have good resolution. Conclusions: The revised method can be used to identify Rhizoma Alismatis in Liuwei Dihuang Pills and other Dihuang pills of Chinese Pharmacopoeia. To achieve the purpose for the same reference drug in different Chinese patent medicines,we can use the same identification method.
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