| 贺澎,王文丽.维生素C片3种含量测定方法的比较[J].中国药品标准,2018,19(2):112-114 |
| 维生素C片3种含量测定方法的比较 |
| Comparison of three methods for determination of Vitamin C tablets |
| 投稿时间：2018-01-08 修订日期：2018-04-10 |
| DOI： |
| 中文关键词: 维生素C片 高效液相色谱法 紫外-可见光分光光度法 碘量法 |
| 英文关键词: vitamin C tablet HPLC UV-Vis spectrophotometry iodometry |
| 基金项目: |
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| 摘要点击次数: 583 |
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| 中文摘要: |
| 目的：比较高效液相色谱法、紫外分光光度法和碘量法测定维生素C片含量的可靠性和准确性。方法：参照《中国药典》2015年版及相关文献分别采用高效液相色谱法、紫外-可见光分光光度法、碘量法对维生素C片中维生素C的含量进行测定。结果：高效液相色谱法的含量测定结果为标示量的98.7%～102.4%；紫外-可见光分光光度法的含量测定结果为标示量98.7%～102.1%；碘量法的含量测定结果为标示量98.6%～100.5%，三种方法的含量测定结果均符合2015年版《中国药典》93．0％～107．0％的规定。结论：三种方法的含量测定结果没有显著差异，均可以用于维 |
| 英文摘要: |
| Objective：To compare the reliability and accuracy of High Performance Liquid Chromatography (HPLC), UV-Vis Spectrophotometry and iodometry to determine the content of vitamin C in vitamin C tablets. Methods：Referring to Chinese Pharmacopoeia 2015 and literatures，the content of vitamin C in vitamin C tablets was determined by HPLC, UV-Vis Spectrophotometry and iodimetry. Results: The test results by HPLC fell into 98.7% to 102.4%, the test results by UV-Vis Spectrophotometry fell into 98.7% to 102.1%, and the test results of iodometry fell into 98.6% to 100.5%. The test results by these three methods met the criteria of 93.0% to 107.0% in Chinese Pharmacopoeia 2015. Conclusion：There is no significant difference between the test results of these three methods. These three methods can be used to the quality control of vitamin C tablets. |
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