| 何晓艳,王蓉蓉,肖菁.赖氨葡锌颗粒含量测定方法的修订[J].中国药品标准,2016,17(4):275-278 |
| 赖氨葡锌颗粒含量测定方法的修订 |
| Revision for the Determination Method of Lysine Hydrochloride and Zinc Gluconate Granules |
| 投稿时间：2016-03-24 修订日期：2016-07-08 |
| DOI： |
| 中文关键词: 赖氨葡锌颗粒 葡萄糖酸锌 含量测定 |
| 英文关键词: Lysine Hydrochloride and Zinc Gluconate Granules |
| 基金项目: |
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| 中文摘要: |
| 目的：修订赖氨葡锌颗粒现行标准中葡萄糖酸锌的含量测定方法。方法：络合滴定过程中加入氟化铵试剂。结果：葡萄糖酸锌在139.67~259.38mg范围内呈良好的线性关系（r=0.999 5），平均回收率为100.2%，其RSD为0.24% 。结论：修订后的方法消除了辅料蔗糖对含量测定结果的影响，该方法准确度高，可真实反映药品的含量。 |
| 英文摘要: |
| Objective: To revise the Assay method of current standard of Lysine Hydrochloride and Zinc Gluconate Granules. Method: Ammonium fluoride reagent was added in the process of complexation titration. Result: Zinc gluconate was linear in the range of 139.67~259.38mg (r=0.999 5), the average recovery was 100.24% with RSD of 0.29%. Conclusion: The modified method can eliminate the influence of sucrose on content determination, which is accurate and can truly reflect the actual content of drug. |
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