| 陈默,杨宏伟,王全一,孙苓苓.ICP-MS法测定复方氨基酸注射液中铝元素的含量[J].中国药品标准,2019,20(3):237-241 |
| ICP-MS法测定复方氨基酸注射液中铝元素的含量 |
| Determination of aluminium content in compound amino acid injections by ICP-MS |
| 投稿时间：2018-08-20 修订日期：2019-05-21 |
| DOI： |
| 中文关键词: 电感耦合等离子体质谱 复方氨基酸注射液 铝 |
| 英文关键词: ICP-MS compound amino acid injection aluminum |
| 基金项目:国家科技重大专项, |
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| 中文摘要: |
| 目的：建立复方氨基酸注射液中铝含量的测定方法。方法：采用电感耦合等离子体质谱（ICP-MS）法测定注射液中铝元素含量。结果: 铝浓度在5～200 μg?L-1范围内呈良好的线性关系( r = 0. 9996)；平均回收率为103.2%，RSD为4.5%（18AA）；平均回收率为106.1%，RSD为2.6%（18AA-Ⅰ）。结论: 该方法简便、快速、准确，可用于复方氨基酸注射液中铝的含量测定。不同生产企业的氨基酸注射液中铝残留量存在很大差异，有必要控制复方氨基酸注射液铝的残留量。 |
| 英文摘要: |
| Objective: To establish a detemination method of aluminium content in compound amino acid injection.Method: The ICP-MS method was used for determination of aluminiumin compound amino acid injection．Results: The response of aluminum showed good linearity ( r = 0.9996) in the range of 5-200μg?L-1;the average recoverywas 103.2% with RSD of 4.5%（18AA）;the average recoverywas 106.1% with RSD of 2.6%（18AA-Ⅰ）．Conclusion: The method is simple,rapid,accurate,and can be used for determination of aluminum in compound amino acid injections．There is a significant difference inaluminium content between compoundamino acid injections from differentmanufacturers,and it is necessary to control the residues of aluminum in compound amino acid injections． |
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