| 王超众,王萌萌,孙鹏云,张连成.高效液相色谱法测定那可丁片的含量[J].中国药品标准,2018,19(3):226-229 |
| 高效液相色谱法测定那可丁片的含量 |
| Determination of Naketin Tablets by HPLC |
| 投稿时间：2018-03-05 修订日期：2018-06-13 |
| DOI： |
| 中文关键词: 那可丁 液相色谱 含量测定 |
| 英文关键词: Nacho Liquid chromatography Content determination |
| 基金项目: |
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| 中文摘要: |
| 目的：建立高效液相色谱方法测定那可丁片的含量。方法：采用Agilent氰基柱(4.6μm×150mm,5μm),流动相为0.1mol/磷酸二氢钾(PH6.0)—甲醇(65：35),检测波长240nm,流速1.0ml.min-1,柱温30℃；进样量20μl。结果：那可丁测定的线性范围在4.0～120μg .ml-1(r=0.9995,n=6)进样量与峰面积值呈良好的线性关系；平均加样回收率为99.17%,RSD=1.13(n=9)。结论：本法专属性强,操作简便,结果准确。 |
| 英文摘要: |
| Objective: A high performance liquid chromatography method was established to determine the content of the tablets. Method: Agilent cyanogenic column(4.6 μm X 150 mm, 5 μm), flow phase 0.01 MoLo dihydrogen phosphate(PH6.0)-methanol(65:35), detection wavelength 240 nm, flow rate 1.0 MLL. min-1, column temperature 30, Intake 20 μ。Result: the sample size and the peak area value of 4.0～120μg.ml-1 (r=0.9995, n=6). The average recovery rate was 99.17%, RSD=1.13(n=9). Conclusion: This method has strong specificity, easy operation and accurate results. |
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