| 栾琳,孙会敏.聚维酮K90中三乙醇胺的测定[J].中国药品标准,2018,19(1):77-80 |
| 聚维酮K90中三乙醇胺的测定 |
| GC determination of triethanolamine in povindone K90 |
| 投稿时间：2017-10-20 修订日期：2018-02-08 |
| DOI： |
| 中文关键词: 三乙醇胺 聚维酮K90 气相毛细管色谱法 |
| 英文关键词: triethanolamine povindone K 90 capillary gas chromatography |
| 基金项目: |
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| 摘要点击次数: 735 |
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| 中文摘要: |
| 目的：建立药用辅料聚维酮K90中三乙醇胺的测定方法。方法：采用毛细管气相色谱法,以50%苯基-50%甲基聚硅氧烷为固定液(DB-17,30m×0.32mm,0.25μm),起始温度100℃,以10℃.min-1升温至240℃,保持2分钟,氢火焰离子化检测器,进样口温度260℃,检测器温度290℃,以氮气为载气,流速2mL.min-1,分流比10:1。结果：在选定的色谱条件下,三乙醇胺与内标邻苯二甲酸二乙酯分离良好,样品中的其他成分不干扰测定。以内标法计算,三乙醇胺线性回归方程为Y=0.024C-0.667(r=0.9995),线性范围36.2μg.mL-1～361.8μg.mL-1,平均回收率为95.0%(n=6),精密度为4.5%(n=6),检出限为12.1μg.mL-1,定量限为36.2μg.mL-1。3批聚维酮样品的三乙醇胺的含量均为0.2%。结论：该方法准确、可靠,可用于聚维酮K90中三乙醇胺残留测定,同时为聚维酮其他型号样品中三乙醇胺的测定提供依据。 |
| 英文摘要: |
| Objective: To develop a gas chromatography method for determination of triethanolamine in povindone K90. Methods: The analysis of triehanolamine by capillary gas chromatography with 50% phenyl -50% methyl polysiloxaneS as stationary phase (DB-17, 30m×0.32mm,0.25μm); Initial column temperature was 100℃, then raised temperature to 240℃ at a rate of 10℃.min-1 , and maintain for 2 minutes; The temperature of injection port and hydrogen flame ionization detector were 260℃and 290℃, respectively; Nitrogen as the carrier gas, and flow rate was 2mL/min；Split ratio was 10:1. Results: A good resolution was obtained by this |
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